Xu Laboratory

Structural Sciences

Hormone signaling is essential to eukaryotic life.  Our research is focused on the signaling mechanisms of physiologically important hormones, striving to solve fundamental questions that have a broad impact on human health and disease.  The overall goal of my research program is to seek new biological paradigms through structural and functional analysis of key hormone signaling complexes and to develop therapeutic applications using the structural information we obtain.  My current research programs are focused on two families of proteins, the nuclear hormone receptors and the G protein–coupled receptors, because these proteins, beyond their fundamental roles in biology, are important drug targets for treating major human diseases.